무기인산염 함유 이상성 인산칼슘이 외방성 수직골 형성에 미치는 영향
The effect of micro-macroporous biphasic calcium phosphate incorporated with polyphosphate on exophytic bone regeneration
김동환, 허익, 권영혁, 박준봉, 정종혁,
소속 상세정보
김동환 ( Kim Dong-Hwan ) - 경희대학교 치의학전문대학원 치주과학교실
허익 ( Herr Yeek ) - 경희대학교 치의학전문대학원 치주과학교실
권영혁 ( Kwon Young-Hyuk ) - 경희대학교 치의학전문대학원 치주과학교실
박준봉 ( Park Joon-Bong ) - 경희대학교 치의학전문대학원 치주과학교실
정종혁 ( Chung Jong-Hyuk ) - 경희대학교 치의학전문대학원 치주과학교실
KMID : 0363020080380020179
Abstract
Purpose: In this study, the effect of micro-macroporous biphasic calcium phosphate(MBCP) incorporated with inorganic polyphosphate for bone regeneration in the calvaria of rabbit was evaluated.
Materials and Methods: The procedure of guided bone regeneration was performed with titanium reinforced expanded polytetrafluoroethylene(TR-ePTFE) membrane. Four animal groups were compared : 1) TR-ePTFE membrane for negative control group, 2) TR-ePTFE membrane filled with MBCP for positive control group, 3) TR-ePTFE membrane filled with MBCP soaked in 4% inorganic polyphosphate for experimental group I, and 4) TR-ePTFE membrane filled with MBCP soaked in 8% inorganic polyphosphate for experimental group II.
Results: 1. Negative control group showed the highest new bone formation at 16 weeks. 2. Positive control group showed the smallest new bone formation compared to other groups. 3. 8% inorganic polyphosphate induced more volume of bone formation, otherwise experimental group II did not show significant difference compared to negative control group.
Conclusion: These results suggest that inorganic polyphosphate has a promoting effect on bone regeneration, possibly by enhancing osteoconductivity of the carrier and by increasing osteoinductivity of the defected alveolar bone tissue.
키워드
MBCP;polyphosphate;exophytic bone regeneration
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